Pub. Date : 2020 Jul
PMID : 32678848
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The scaffolding molecule, Ng, when present in significant concentration, limits the availability of free calmodulin (CaM), the protein which activates CaMKII in the presence of calcium. | Calcium | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 2 | We show that Ng plays an important modulatory role in CaMKII phosphorylation following a surge of high calcium concentration. | Calcium | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 3 | We find a non-intuitive dependence of this effect on CaM concentration that results from the different affinities of CaM for CaMKII depending on the number of calcium ions bound to the former. | Calcium | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 4 | We also study the effect of multiple calcium spikes on CaMKII holoenzyme autophosphorylation, and show that in the presence of phosphatase, CaMKII behaves as a leaky integrator of calcium signals, a result that has been recently observed in vivo. | Calcium | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 5 | We also study the effect of multiple calcium spikes on CaMKII holoenzyme autophosphorylation, and show that in the presence of phosphatase, CaMKII behaves as a leaky integrator of calcium signals, a result that has been recently observed in vivo. | Calcium | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 6 | Our models predict that the parameters of this leaky integrator are finely tuned through the interactions of Ng, CaM, CaMKII, and PP1, providing a mechanism to precisely control the sensitivity of synapses to calcium signals. | Calcium | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |