Pub. Date : 1988 Dec
PMID : 3266728
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For 6 of 10 beta-lactamase-positive strains, there was a greater-than-twofold-dilution reduction in oxacillin MICs with the addition of clavulanic acid or sulbactam. | Clavulanic Acid | beta-lactamase | Staphylococcus aureus |
| 2 | Of the four strains that became resistant with incubation at the lower temperature, a clavulanic acid effect was observed in three but only at 35 degrees C. The oxacillin MIC for one of the beta-lactamase-negative strains was also reduced with clavulanic acid; however, this strain was inhibited by 1 microgram of clavulanic acid per ml alone. | Clavulanic Acid | beta-lactamase | Staphylococcus aureus |
| 3 | Of the four strains that became resistant with incubation at the lower temperature, a clavulanic acid effect was observed in three but only at 35 degrees C. The oxacillin MIC for one of the beta-lactamase-negative strains was also reduced with clavulanic acid; however, this strain was inhibited by 1 microgram of clavulanic acid per ml alone. | Clavulanic Acid | beta-lactamase | Staphylococcus aureus |
| 4 | Of the four strains that became resistant with incubation at the lower temperature, a clavulanic acid effect was observed in three but only at 35 degrees C. The oxacillin MIC for one of the beta-lactamase-negative strains was also reduced with clavulanic acid; however, this strain was inhibited by 1 microgram of clavulanic acid per ml alone. | Clavulanic Acid | beta-lactamase | Staphylococcus aureus |
| 5 | Bactericidal activity was observed with two or four times the oxacillin MIC in eight strains tested at both temperatures, and the combination with clavulanic acid was bactericidal at higher than four times the MIC in five of the strains at 30 degrees C. Our results suggest that oxacillin intermediate MICs for staphylococcal isolates are due not only to beta-lactamase hyperproduction but also some other unidentified factor. | Clavulanic Acid | beta-lactamase | Staphylococcus aureus |