Pub. Date : 2020 Jul 11
PMID : 32652973
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 - secondary analysis of a randomized controlled trial. | Metformin | insulin like growth factor binding protein 1 | Homo sapiens |
| 2 | We studied whether metformin treatment has favorable or unfavorable effects on inflammatory markers and insulin-like growth factor-binding protein 1 (IGFBP-1) in GDM patients compared with insulin, and whether these markers associate with major maternal or fetal clinical outcomes. | Metformin | insulin like growth factor binding protein 1 | Homo sapiens |
| 3 | We studied whether metformin treatment has favorable or unfavorable effects on inflammatory markers and insulin-like growth factor-binding protein 1 (IGFBP-1) in GDM patients compared with insulin, and whether these markers associate with major maternal or fetal clinical outcomes. | Metformin | insulin like growth factor binding protein 1 | Homo sapiens |
| 4 | GlycA (p = 0.02) and non-phosphorylated IGFBP-1 (p = 0.008) increased more in patients treated with metformin than those treated with insulin. | Metformin | insulin like growth factor binding protein 1 | Homo sapiens |
| 5 | CONCLUSIONS: Metformin had beneficial effects on maternal serum IGFBP-1 concentrations compared to insulin, as increased IGFBP-1 related to lower total and late pregnancy maternal weight gain. | Metformin | insulin like growth factor binding protein 1 | Homo sapiens |