Title : Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial.

Pub. Date : 2020 Sep 15

PMID : 32646922






1 Functional Relationships(s)
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1 In both humans and mice, metformin triggered AMPK activation and STAT3 inactivation, and altered the production of effector cytokines (i.e. TNF-alpha, IFN-gamma, IL-10) in the immune cells. Metformin tumor necrosis factor Homo sapiens