Title : Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway.

Pub. Date : 2020 Sep 15

PMID : 32645343






2 Functional Relationships(s)
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1 In the present study, we aimed to use BIBR1532, an hTERT inhibitor, in combination with ATO to sensitize MCF7 and MDA-231 cells to lower concentrations of ATO. Arsenic Trioxide telomerase reverse transcriptase Homo sapiens
2 SIGNIFICANCE: The combination of ATO and BIBR1532 synergistically induced its anti-proliferative effect in breast cancer cells by targeting the two key cancer-related pathways, hTERT and NF-kappaB, and disrupting their feed-forward loop at the same time which result in the reduction of NF-kappaB transcriptional activity and subsequent down-regulation of its target genes. Arsenic Trioxide telomerase reverse transcriptase Homo sapiens