Title : In Silico Studies and In Vivo MAOA Inhibitory Activity of Coumarins Isolated from Angelica archangelica Extract: An Approach toward Antidepressant Activity.

Pub. Date : 2020 Jun 30

PMID : 32637779






3 Functional Relationships(s)
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1 The current investigation was aimed at in vivo MAOA inhibitory activity of coumarins angelicin, bergapten, and scopoletin isolated from the roots of Angelica archangelica. 5-Methoxypsoralen monoamine oxidase A Mus musculus
2 The molecular docking results displayed that bergapten has a maximum affinity for MAOA, followed by angelicin and scopoletin. 5-Methoxypsoralen monoamine oxidase A Mus musculus
3 Biochemical examination of the brain tissue indicated that bergapten has maximum MAOA inhibitory activity while scopoletin fails to inhibit brain MAOA. 5-Methoxypsoralen monoamine oxidase A Mus musculus