Pub. Date : 2020 Jul
PMID : 32627027
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exposure of the cells to TGF-beta1 activated the Smad2/3 and Akt/mammalian target of rapamycin (mTOR) pathways, and this effect was inhibited by metformin, suggesting that metformin inhibits TGF-beta1-induced-EMT through the down-regulation of the Smad pathway in PANC-1 cells and the downregulation of the Akt/mTOR pathway in BxPC-3 cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Exposure of the cells to TGF-beta1 activated the Smad2/3 and Akt/mammalian target of rapamycin (mTOR) pathways, and this effect was inhibited by metformin, suggesting that metformin inhibits TGF-beta1-induced-EMT through the down-regulation of the Smad pathway in PANC-1 cells and the downregulation of the Akt/mTOR pathway in BxPC-3 cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Exposure of the cells to TGF-beta1 activated the Smad2/3 and Akt/mammalian target of rapamycin (mTOR) pathways, and this effect was inhibited by metformin, suggesting that metformin inhibits TGF-beta1-induced-EMT through the down-regulation of the Smad pathway in PANC-1 cells and the downregulation of the Akt/mTOR pathway in BxPC-3 cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Exposure of the cells to TGF-beta1 activated the Smad2/3 and Akt/mammalian target of rapamycin (mTOR) pathways, and this effect was inhibited by metformin, suggesting that metformin inhibits TGF-beta1-induced-EMT through the down-regulation of the Smad pathway in PANC-1 cells and the downregulation of the Akt/mTOR pathway in BxPC-3 cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | On the whole, the findings of the present study suggest that metformin inhibits EMT and cancer metastasis through the Smad or Akt/mTOR pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |