Pub. Date : 2020 Aug
PMID : 32627020
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tubeimoside-1 induces apoptosis in human glioma U251 cells by suppressing PI3K/Akt-mediated signaling pathways. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The present study explored TBMS1-induced PI3K/Akt-related pathways in human glioma cells. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The results demonstrated that TBMS1 reduced cell viability in human glioma cells U251 by suppressing Akt phosphorylation. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Subsequently, TBMS1 inhibited DNA synthesis and induced G2/M phase arrest by targeting the PI3K/Akt/p21 and the cyclin-dependent kinase 1/cyclin B1 signaling cascades. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | In addition, TBMS1 triggered apoptosis via the PI3K/Akt-mediated Bcl-2 signaling pathway. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | These results demonstrated that TBMS1 prevented the progression of gliomas via the PI3K/Akt-dependent pathway, which provided a theoretical basis for in vivo studies to use TBMS1 as potential therapy for the prevention of cancer. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | These results demonstrated that TBMS1 prevented the progression of gliomas via the PI3K/Akt-dependent pathway, which provided a theoretical basis for in vivo studies to use TBMS1 as potential therapy for the prevention of cancer. | tubeimoside I | AKT serine/threonine kinase 1 | Homo sapiens |