Title : CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity.

Pub. Date : 2021 Aug 1

PMID : 32616529






1 Functional Relationships(s)
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1 In primary AML BM samples from patients and the OCI-AML3 cell line, CD44 engagement by hyaluronan induced inside-out activation of VLA-4 resulting in enhanced leukemia cell adhesion on VCAM-1. Hyaluronic Acid CD44 molecule (Indian blood group) Homo sapiens