Title : Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation.

Pub. Date : 2020 Jul 15

PMID : 32616181






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HMGCR is subject to layers of negative feedback loops; excess cholesterol inhibits transcription of the gene, and lanosterols and oxysterols accelerate degradation of HMGCR. Lanosterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 HMGCR is subject to layers of negative feedback loops; excess cholesterol inhibits transcription of the gene, and lanosterols and oxysterols accelerate degradation of HMGCR. Lanosterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens