Title : Effect of Maintenance Intravenous Iron Treatment on Erythropoietin Dose in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial.

Pub. Date : 2020

PMID : 32612843






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Effect of Maintenance Intravenous Iron Treatment on Erythropoietin Dose in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial. Iron erythropoietin Homo sapiens
2 Objective: To examine the effect of IV iron supplementation to different targets of serum ferritin on erythropoietin dose and inflammatory markers in chronic hemodialysis (HD) patients with functional iron deficiency anemia. Iron erythropoietin Homo sapiens
3 The erythropoietin resistance index was significantly decreased in the high-serum ferritin group compared to the low-serum ferritin group after receiving IV iron in the 6-week titration period (mean difference: -113.43 +- 189.14 vs 41.08 +- 207.38 unit/week/g/dL; P < .001) and 3-month follow-up period (mean differences: -88.88 +- 234.43 vs -10.48 +- 217.75 unit/week/g/dL; P = .02). Iron erythropoietin Homo sapiens
4 Conclusion: Maintaining a serum ferritin level of 600 to 700 ng/mL by IV iron administration of approximately 200 mg per month as a maintenance protocol can decrease erythropoietin dose requirements in chronic HD patients with functional iron deficiency anemia. Iron erythropoietin Homo sapiens