Title : Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research.

Pub. Date : 2020

PMID : 32587790






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TNF-alpha progressively increased the apoptotic cells at 48 and 72 h. Conclusion: At 0.008 microM of TNF-alpha, an IR condition was induced in hTeno, supported with the significant reduction in glucose uptake, as well as significantly reduced total collagen, specifically COL-I expression levels, downregulation of candidate tenogenic markers genes (SCX and MKX), and upregulation of ECM catabolic genes (MMP-9 and MMP-13). Glucose tumor necrosis factor Homo sapiens
2 TNF-alpha progressively increased the apoptotic cells at 48 and 72 h. Conclusion: At 0.008 microM of TNF-alpha, an IR condition was induced in hTeno, supported with the significant reduction in glucose uptake, as well as significantly reduced total collagen, specifically COL-I expression levels, downregulation of candidate tenogenic markers genes (SCX and MKX), and upregulation of ECM catabolic genes (MMP-9 and MMP-13). Glucose tumor necrosis factor Homo sapiens