Title : Metabolism of inositol bis-, tris-, tetrakis- and pentakis-phosphates in GH3 cells.

Pub. Date : 1988 Mar 1

PMID : 3258515






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 I(1,4,5)P3 is either phosphorylated to I(1,3,4,5)P4 (in the presence of ATP) or dephosphorylated to I(1,4)P2 (in the absence of ATP). Triphosphoinositol protein phosphatase 1, regulatory (inhibitor) subunit 1A Rattus norvegicus
2 These data suggest two main routes of metabolism for I(1,4,5)P3 in GH3 cells: either (1) phosphorylation to I(1,3,4,5)P4, and the subsequent consecutive dephosphorylation to I(1,3,4)P3, I(3,4)P2 and finally L-I(1)P [D-I(3)P]; or (2) dephosphorylation to I(1,4)P2 and, subsequently, I(4)P. Triphosphoinositol protein phosphatase 1, regulatory (inhibitor) subunit 1A Rattus norvegicus