Title : In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors.

Pub. Date : 1988 Apr

PMID : 3258496






2 Functional Relationships(s)
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1 The plasma clearance of 125I-labeled human heparin cofactor II and its complex with thrombin was studied in mice to determine whether a specific mechanism exists for the catabolism of the inhibitor-proteinase complex. Iodine-125 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus
2 The results demonstrated that the clearance of 125I-labeled heparin cofactor II-alpha-thrombin is a receptor-mediated process, and that the same hepatocyte receptor system recognizes complexes containing heparin cofactor II, antithrombin III, and alpha 1-proteinase inhibitor. Iodine-125 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus