Title : 12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1.

Pub. Date : 2020 Sep 1

PMID : 32584793






1 Functional Relationships(s)
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1 Both 12(S)-HETE in concentrations found in diabetic patients and TRPV1 agonists triggered mitochondrial calcium influx and mitochondrial dysfunction in endothelial cells and 12(S)-HETE effects were absent in endothelial cells from TRPV1 knock out mice. Calcium transient receptor potential cation channel subfamily V member 1 Homo sapiens