Pub. Date : 2020 Jul 15
PMID : 32571843
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells. | Cysteine | major histocompatibility complex, class I, C | Homo sapiens |
| 2 | Nevertheless, prediction algorithms appear to function poorly for epitopes containing cysteine (Cys) residues, which can oxidize and form disulfide bonds with other Cys residues under oxidizing conditions, thus potentially interfering with their ability to bind to MHC molecules. | Cysteine | major histocompatibility complex, class I, C | Homo sapiens |
| 3 | Nevertheless, prediction algorithms appear to function poorly for epitopes containing cysteine (Cys) residues, which can oxidize and form disulfide bonds with other Cys residues under oxidizing conditions, thus potentially interfering with their ability to bind to MHC molecules. | Cysteine | major histocompatibility complex, class I, C | Homo sapiens |
| 4 | Substitutions of AABA for Cys at putative MHC anchor positions often significantly enhanced T cell recognition, whereas substitutions at non-MHC anchor positions were neutral, except for one epitope where this modification abolished T cell recognition. | Cysteine | major histocompatibility complex, class I, C | Homo sapiens |