Title : Biological effects of chronic and acute exposure of human endothelial cell line EA.hy926 to bisphenol A: New tricks from an old dog.

Pub. Date : 2020 Oct

PMID : 32559890






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using Western blotting and specific pharmacological inhibitors in the acute study, we have shown that direct BPA"s action in EA.hy926 cells involves activation of estrogen receptor (ER), phosphorylation of protein kinase B (PKB/Akt) and endothelial nitric oxide synthase (eNOS)-mediated production of NO. bisphenol A estrogen receptor 1 Homo sapiens
2 Using Western blotting and specific pharmacological inhibitors in the acute study, we have shown that direct BPA"s action in EA.hy926 cells involves activation of estrogen receptor (ER), phosphorylation of protein kinase B (PKB/Akt) and endothelial nitric oxide synthase (eNOS)-mediated production of NO. bisphenol A estrogen receptor 1 Homo sapiens
3 Collectively, these data indicate that BPA induces functional and molecular changes in EA.hy926 cells associated with the promotion of endothelial integrity through activation of the ER/Akt/eNOS pathway. bisphenol A estrogen receptor 1 Homo sapiens