Title : Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins.

Pub. Date : 2020 Jul 1

PMID : 32556248






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors. N-Acetylneuraminic Acid cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens
2 Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors. N-Acetylneuraminic Acid cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens