Pub. Date : 2020 Jul 1
PMID : 32556248
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors. | N-Acetylneuraminic Acid | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | Homo sapiens |
2 | Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors. | N-Acetylneuraminic Acid | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | Homo sapiens |