Title : Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins.

Pub. Date : 2020 Jul 1

PMID : 32556248






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The mutation likely altered human SAMPs, triggering multiple events, including emergence of human-adapted pathogens with strong preference for Neu5Ac recognition and/or presenting Neu5Ac-containing molecular mimics of human glycans, which can suppress immune responses via CD33-related-Siglec engagement. Polysaccharides CD33 molecule Homo sapiens