Title : Silica nanoparticles induce spermatogenesis disorders via L3MBTL2-DNA damage-p53 apoptosis and RNF8-ubH2A/ubH2B pathway in mice.

Pub. Date : 2020 Oct

PMID : 32554096






2 Functional Relationships(s)
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1 Results revealed that exposure to SiNPs induced reduction in the rate of sperm activity, histological abnormalities in seminiferous epithelium as well as apoptosis of spermatogenic cells, which are associated with decreased level of Lethal (3) malignant brain tumor like 2 (L3MBTL2) and activation of DNA damage-p53-mitochondrial apoptosis pathways. sinps L3MBTL2 polycomb repressive complex 1 subunit Mus musculus
2 This indicates that L3MBTL2 plays an important role in reproductive toxicity of males caused by SiNPs. sinps L3MBTL2 polycomb repressive complex 1 subunit Mus musculus