Pub. Date : 2020 May 20
PMID : 32553076
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine Attenuates High Glucose-induced HK-2 Epithelial-mesenchymal Transition by Inhibiting AKT and ERK. | Glucose | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Results: Compared with HK-2 cells exposed to high level of glucose, the HK-2 cells exposed to both high level of glucose and Dex showed: (1) lower level of ROS production; (2) cell morphology was complete; (3) more cells in G1 phase; (4) lower expression of p-AKT, p-ERK and alpha-SMA, higher expression of E-Cadherin and Claudin-1. | Glucose | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Conclusion: Dex can attenuate high glucose-induced HK-2 epithelial-mesenchymal transition by inhibiting AKT and ERK. | Glucose | AKT serine/threonine kinase 1 | Homo sapiens |