Pub. Date : 2020 Dec
PMID : 32550560
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose and TNF enhance expression of TNF and IL1B, and histone H3 acetylation and K4/K36 methylation, in juvenile macrophage cells. | Glucose | tumor necrosis factor | Homo sapiens |
| 2 | In this study, we investigated whether high glucose and/or tumor necrosis factor (TNF) would enhance pro-inflammatory cytokine expression of tumor necrosis factor (TNF) and interleukin (IL)-1beta (IL1B) by altering histone modifications in U937, a juvenile macrophage cell line. | Glucose | tumor necrosis factor | Homo sapiens |
| 3 | In this study, we investigated whether high glucose and/or tumor necrosis factor (TNF) would enhance pro-inflammatory cytokine expression of tumor necrosis factor (TNF) and interleukin (IL)-1beta (IL1B) by altering histone modifications in U937, a juvenile macrophage cell line. | Glucose | tumor necrosis factor | Homo sapiens |
| 4 | The mRNA levels of TNF and IL1B in U937 cells were significantly affected by glucose concentration and TNF treatment. | Glucose | tumor necrosis factor | Homo sapiens |
| 5 | Mono-methylated histone H3K4 signals around TNF and IL1B were lower in cells treated with high glucose compared with low glucose. | Glucose | tumor necrosis factor | Homo sapiens |
| 6 | Mono-methylated histone H3K4 signals around TNF and IL1B were lower in cells treated with high glucose compared with low glucose. | Glucose | tumor necrosis factor | Homo sapiens |
| 7 | TNF treatment of U937 cells cultured in high glucose enhanced histone H3K36 tri-methylation, particularly around the gene regions of TNF and IL1B. | Glucose | tumor necrosis factor | Homo sapiens |
| 8 | TNF treatment of U937 cells cultured in high glucose enhanced histone H3K36 tri-methylation, particularly around the gene regions of TNF and IL1B. | Glucose | tumor necrosis factor | Homo sapiens |
| 9 | Histone acetylation was induced by treatment with TNF in high-glucose medium. | Glucose | tumor necrosis factor | Homo sapiens |
| 10 | The induction of acetylation and tri-methylation of K4 and K36 of histone H3 around TNF and IL1B by treatment with high glucose and/or TNF was positively associated with the induction of these genes in juvenile macrophage U937 cells. | Glucose | tumor necrosis factor | Homo sapiens |