Pub. Date : 2020 Jul 9
PMID : 32544384
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysosomal cholesterol egress requires two proteins, NPC1 and NPC2, whose defects are responsible for Niemann-Pick disease type C (NPC). | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | Here, we present systematic structural characterizations that reveal the molecular basis for low-pH-dependent cholesterol delivery from NPC2 to the transmembrane (TM) domain of NPC1. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | Finally, the structure of the NPC1-NPC2 complex at 4.0 A resolution was obtained at pH 5.5, elucidating the molecular basis for cholesterol handoff from NPC2 to NPC1(NTD). | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | Finally, the structure of the NPC1-NPC2 complex at 4.0 A resolution was obtained at pH 5.5, elucidating the molecular basis for cholesterol handoff from NPC2 to NPC1(NTD). | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |