Title : Inhibitory effect of sixteen pharmaceutical excipients on six major organic cation and anion uptake transporters.

Pub. Date : 2021 Jan

PMID : 32544367






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tween 20 inhibits hOCT2, hOAT1, hOAT3, and hOATP1B3 in a mixed way, whereas it competitively inhibits hOATP1B1. Polysorbates solute carrier family 22 member 6 Homo sapiens
2 The inhibition of Tween 80 is competitive for hOCT2, non-competitive for hOATP1B1 and hOATP1B3, and mixed for hOAT1 and hOAT3. Polysorbates solute carrier family 22 member 6 Homo sapiens