Title : Nuclear respiratory factor 1 (NRF-1) upregulates the expression and function of reduced folate carrier (RFC) at the blood-brain barrier.

Pub. Date : 2020 Aug

PMID : 32543769






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC). Folic Acid rabaptin, RAB GTPase binding effector protein 2 Mus musculus
2 Brain folate transport primarily occurs at the choroid plexus through FRalpha and PCFT; inactivation of these transport systems results in suboptimal folate levels in the cerebrospinal fluid (CSF) causing childhood neurological disorders. Folic Acid rabaptin, RAB GTPase binding effector protein 2 Mus musculus