Pub. Date : 2020 Jun 15
PMID : 32540853
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It has been noted that MFS and UPS frequently lose function of the tumor suppressor genes RB1 and TP53 In this issue of Cancer Research, Li and colleagues demonstrate that proliferation in RB1- and TP53-deficient MFS and UPS depends on SKP2; inhibiting SKP2 with the neddylation inhibitor, pevonedistat, halts tumor growth in a panel of patient-derived xenografts. | pevonedistat | tumor protein p53 | Homo sapiens |