Pub. Date : 2021 Mar
PMID : 32536326
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Application of goal-directed therapy for the use of concentrated antithrombin for heparin resistance during cardiac surgery. | Heparin | serpin family C member 1 | Homo sapiens |
| 2 | The purpose of this study was to evaluate a goal-directed approach for the use of antithrombin in patients who were resistant to heparin. | Heparin | serpin family C member 1 | Homo sapiens |
| 3 | A goal-directed protocol for antithrombin was established based upon heparin dosing (400 IU kg-1 body weight) and achieving an activated clotting time of >=500 seconds prior to cardiopulmonary bypass. | Heparin | serpin family C member 1 | Homo sapiens |
| 4 | Patients in the antithrombin group were on preoperative heparin therapy (80.0% vs. 24.6%, p = 0.001). | Heparin | serpin family C member 1 | Homo sapiens |
| 5 | Antithrombin patients had a lower heparin sensitivity index (0.55 +- 0.17 vs. 1.05 +- 0.44 seconds heparin-1 IU kg-1, p = 0.001), received more total heparin (961.3 +- 158.5 IU kg-1 vs. 677.5 +- 199.0 IU kg-1, p = 0.001), more cardiopulmonary bypass heparin (22,500 +- 10,300 IU vs. 12,100 +- 13,200 IU, p = 0.016), and more protamine (5.4 +- 1.2 vs. 4.1 +- 1.1 mg kg-1, p = 0.003). | Heparin | serpin family C member 1 | Homo sapiens |
| 6 | Antithrombin patients had a lower heparin sensitivity index (0.55 +- 0.17 vs. 1.05 +- 0.44 seconds heparin-1 IU kg-1, p = 0.001), received more total heparin (961.3 +- 158.5 IU kg-1 vs. 677.5 +- 199.0 IU kg-1, p = 0.001), more cardiopulmonary bypass heparin (22,500 +- 10,300 IU vs. 12,100 +- 13,200 IU, p = 0.016), and more protamine (5.4 +- 1.2 vs. 4.1 +- 1.1 mg kg-1, p = 0.003). | Heparin | serpin family C member 1 | Homo sapiens |
| 7 | Antithrombin patients had a lower heparin sensitivity index (0.55 +- 0.17 vs. 1.05 +- 0.44 seconds heparin-1 IU kg-1, p = 0.001), received more total heparin (961.3 +- 158.5 IU kg-1 vs. 677.5 +- 199.0 IU kg-1, p = 0.001), more cardiopulmonary bypass heparin (22,500 +- 10,300 IU vs. 12,100 +- 13,200 IU, p = 0.016), and more protamine (5.4 +- 1.2 vs. 4.1 +- 1.1 mg kg-1, p = 0.003). | Heparin | serpin family C member 1 | Homo sapiens |
| 8 | Antithrombin patients had a lower heparin sensitivity index (0.55 +- 0.17 vs. 1.05 +- 0.44 seconds heparin-1 IU kg-1, p = 0.001), received more total heparin (961.3 +- 158.5 IU kg-1 vs. 677.5 +- 199.0 IU kg-1, p = 0.001), more cardiopulmonary bypass heparin (22,500 +- 10,300 IU vs. 12,100 +- 13,200 IU, p = 0.016), and more protamine (5.4 +- 1.2 vs. 4.1 +- 1.1 mg kg-1, p = 0.003). | Heparin | serpin family C member 1 | Homo sapiens |
| 9 | Utilization of a goal-directed algorithm for the administration of antithrombin for the treatment of heparin resistance is effective in patients undergoing cardiac surgery. | Heparin | serpin family C member 1 | Homo sapiens |