Pub. Date : 2020 Jun 10
PMID : 32532094
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here we established a quantitative fusion assay dependent on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S protein, angiotensin I converting enzyme 2 (ACE2) and TMPRSS2, and found that nafamostat mesylate potently inhibited the fusion while camostat mesylate was about 10-fold less active. | nafamostat | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | Together, our study shows that nafamostat mesylate potently inhibits SARS-CoV-2 S protein-mediated fusion in a cell fusion assay system and also inhibits SARS-CoV-2 infection in vitro in a cell-type-dependent manner. | nafamostat | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |