Pub. Date : 2020
PMID : 32528731
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 2 | We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 3 | We show that CAFs produce interleukin-6 (IL-6), and that IL-6 attenuates p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 4 | We show that CAFs produce interleukin-6 (IL-6), and that IL-6 attenuates p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. | Doxorubicin | tumor protein p53 | Homo sapiens |