Pub. Date : 2020 May
PMID : 32504383
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of inhibition of the tumor suppressor p53 on the antioxidant system genes expression under the influence of cytotoxic compounds of the platinum group was studied. | Platinum | tumor protein p53 | Homo sapiens |
| 2 | It was found that the action of platinum(II) and platinum(IV) complexes induced accumulation of p53 protein with a maximum in 12 h, which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. | Platinum | tumor protein p53 | Homo sapiens |
| 3 | It was found that the action of platinum(II) and platinum(IV) complexes induced accumulation of p53 protein with a maximum in 12 h, which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. | Platinum | tumor protein p53 | Homo sapiens |
| 4 | It was found that the action of platinum(II) and platinum(IV) complexes induced accumulation of p53 protein with a maximum in 12 h, which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. | Platinum | tumor protein p53 | Homo sapiens |
| 5 | It was found that the action of platinum(II) and platinum(IV) complexes induced accumulation of p53 protein with a maximum in 12 h, which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. | Platinum | tumor protein p53 | Homo sapiens |
| 6 | Suppression of p53 protein functions with specific inhibitor alpha-piphitrin under the action of platinum complexes reduced the expression of catalase and superoxide dismutase 2 genes and the target gene P21, which attested to the p53-dependent regulation of these genes. | Platinum | tumor protein p53 | Homo sapiens |
| 7 | Suppression of p53 protein functions with specific inhibitor alpha-piphitrin under the action of platinum complexes reduced the expression of catalase and superoxide dismutase 2 genes and the target gene P21, which attested to the p53-dependent regulation of these genes. | Platinum | tumor protein p53 | Homo sapiens |