Title : Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.

Pub. Date : 2020 Jun 4

PMID : 32499479






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 These fragments represent a starting point to develop ALAS2 inhibitors as substrate reduction therapy for porphyria disorders that accumulate toxic heme intermediates. Heme 5'-aminolevulinate synthase 2 Homo sapiens