Pub. Date : 2020 Jun
PMID : 32487604
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 2 | The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation of membrane-tethered pro-heparin-binding EGF-like growth factor and the MAPK/ERK pathway. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 3 | RESULTS: Many similarities on the effect of CCL18 on the already known estradiol-activated signaling pathway via the G protein-coupled estrogen receptor GPR30 were identified. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 4 | This is a rather unexpected result, because the estrogen estradiol and CCL18 both activate GPR30. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 5 | CCL18 and estradiol may not lead to the same signaling pathway after activating GPR30. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |