Title : Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents.

Pub. Date : 2020 Jun

PMID : 32468080






2 Functional Relationships(s)
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Protein Name
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1 This correlated with differential upregulation of p53/p21 pathway, with S and G2/M arrests by cisplatin and satraplatin in contrast to G1 arrest by oxaliplatin and DAP. Oxaliplatin H3 histone pseudogene 16 Homo sapiens
2 CONCLUSIONS: Oxaliplatin and DAP robustly activate p53 and p21, which downregulate HR proteins to enhance drug activity. Oxaliplatin H3 histone pseudogene 16 Homo sapiens