Title : Upregulation of Nav1.7 by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.

Pub. Date : 2020 Aug

PMID : 32468069






1 Functional Relationships(s)
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1 Hydrogen sulfide (H2S) has recently been reported to be involved in numerous biological functions, and it has been shown that H2S can enhance the sodium current density, and inhibiting the endogenous production of H2S mediated by cystathionine beta-synthetase (CBS) using O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA) can significantly reduce the expression of Nav1.7 and thus the sodium current density in rat dorsal root ganglion (DRG) neurons. Hydrogen Sulfide cystathionine beta synthase Rattus norvegicus