Title : Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action.

Pub. Date : 2020 May 26

PMID : 32466567






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Molecular mechanisms of ThDP action on cellular viability and their interplay with the cisplatin and p53-p21 pathways are characterized. Thiamine Pyrophosphate H3 histone pseudogene 16 Homo sapiens
2 Cellular levels of the catalytically competent ThDP OGDHC holoenzyme are dysregulated by p21 knockdown and correlate negatively with the A549 viability. Thiamine Pyrophosphate H3 histone pseudogene 16 Homo sapiens
3 The similarity, non-additivity, and p21 dependence of the dual actions of ThDP and cisplatin on A549 cells manifest a common OGDHC-mediated mechanism of the viability decrease. Thiamine Pyrophosphate H3 histone pseudogene 16 Homo sapiens
4 High ThDP saturation of OGDHC compromises the redox state of A549 cells under the control of p53-p21 axes. Thiamine Pyrophosphate H3 histone pseudogene 16 Homo sapiens