Title : Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice.

Pub. Date : 2020 Dec 10

PMID : 32453814






2 Functional Relationships(s)
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1 BACKGROUND: We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose under-functioning is linked to neuroplasticity and depression. Bile Acids and Salts nuclear receptor subfamily 1, group H, member 4 Mus musculus
2 BACKGROUND: We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose under-functioning is linked to neuroplasticity and depression. Bile Acids and Salts nuclear receptor subfamily 1, group H, member 4 Mus musculus