Pub. Date : 2020 Jun 9
PMID : 32444490
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1. | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 2 | Mechanistically, the mutated KRAS oncoprotein hypermethylates and silences the expression of multidrug and toxic compound extrusion 1 (MATE1), a specific pump that expels metformin from the tumor cells by up-regulating DNA methyltransferase 1 (DNMT1). | Metformin | solute carrier family 47 member 1 | Homo sapiens |
| 3 | Our findings provide evidence that KRAS-mutation mCRC patients benefit from metformin treatment and targeting MATE1 may provide a strategy to improve the anticancer response of metformin. | Metformin | solute carrier family 47 member 1 | Homo sapiens |