Pub. Date : 2020 Aug
PMID : 32439826
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential Phosphorylation of the Transcription Factor WRKY33 by the Protein Kinases CPK5/CPK6 and MPK3/MPK6 Cooperatively Regulates Camalexin Biosynthesis in Arabidopsis. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 2 | Here, we report that the pathogen-responsive CALCIUM-DEPENDENT PROTEIN KINASE5 (CPK5) and CPK6 also regulate camalexin biosynthesis in Arabidopsis. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 3 | Chemically induced expression of constitutively active CPK5 or CPK6 variants was sufficient to induce camalexin biosynthesis in transgenic Arabidopsis plants. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 4 | Consistently, the simultaneous mutation of CPK5 and CPK6 compromised camalexin production in Arabidopsis induced by the fungal pathogen Botrytis cinerea. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 5 | Moreover, we identified that WRKY33 functions downstream of CPK5/CPK6 to activate camalexin biosynthetic genes, thereby inducing camalexin biosynthesis. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 6 | Moreover, we identified that WRKY33 functions downstream of CPK5/CPK6 to activate camalexin biosynthetic genes, thereby inducing camalexin biosynthesis. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 7 | Furthermore, both gain- and loss-of-function genetic analyses demonstrated the cooperative regulation of camalexin biosynthesis by CPK5/CPK6 and MPK3/MPK6. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |
| 8 | Taken together, these findings indicate that WRKY33 functions as a convergent substrate of CPK5/CPK6 and MPK3/MPK6, which cooperatively regulate camalexin biosynthesis via the differential phospho-regulation of WRKY33 activity. | camalexin | Calcium-dependent protein kinase family protein | Arabidopsis thaliana |