Title : Mitochondrial Genome-Derived circRNA mc-COX2 Functions as an Oncogene in Chronic Lymphocytic Leukemia.

Pub. Date : 2020 Jun 5

PMID : 32438315






3 Functional Relationships(s)
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1 The endogenous reduction of mc-COX2 can affect mitochondrial functions, suppress cell proliferation, and induce cell apoptosis. Methylcholanthrene mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 We also screened and tested several chemical compounds and small-molecule inhibitors that can decrease the generation of mc-COX2. Methylcholanthrene mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 It was found that the silencing of mc-COX2 in CLL cells strengthened the anti-tumor effects of drugs used in coordination. Methylcholanthrene mitochondrially encoded cytochrome c oxidase II Homo sapiens