Title : The leaving group in Au(I)-phosphine compounds dictates cytotoxic pathways in CEM leukemia cells and reactivity towards a Cys2His2 model zinc finger.

Pub. Date : 2020 Nov 25

PMID : 32432260






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Protein expression profile sets [Au(dmap)(Et3P)]+ further apart from auranofin, with proteolytic degradation of caspase-3 and poly(ADP-ribose)-polymerase (PARP), DNA strand-break induced phosphorylation of Chk2 Thr68 and increased p53 ser15 phosphorylation. Auranofin tumor protein p53 Homo sapiens