Title : Inactivation of dopamine beta-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides.

Pub. Date : 1988 Dec 27

PMID : 3242615






3 Functional Relationships(s)
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1 Recently, p-cresol has been shown to be a mechanism-based inhibitor of dopamine beta-hydroxylase (DBH; EC 1.14.17.1) [Goodhart, P. J., DeWolf, W. E., Jr., & Kruse, L. I. 4-cresol dopamine beta-hydroxylase Homo sapiens
2 Recently, p-cresol has been shown to be a mechanism-based inhibitor of dopamine beta-hydroxylase (DBH; EC 1.14.17.1) [Goodhart, P. J., DeWolf, W. E., Jr., & Kruse, L. I. 4-cresol dopamine beta-hydroxylase Homo sapiens
3 In support of this hypothesis, we report here the isolation and characterization of two modified tryptic peptides from DBH inactivated by p-cresol. 4-cresol dopamine beta-hydroxylase Homo sapiens