Title : Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis.

Pub. Date : 2020 May 15

PMID : 32415082






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LDHB knockdown caused downregulation of mitochondrial functions in auditory cell line, University of Bristol/organ of Corti 1 (UB/OC1) with decreased NAD+ and increased hypoxia inducing factor-1alpha. NAD lactate dehydrogenase B Mus musculus
2 On the contrary, the induction of LDHB expression caused enhanced mitochondrial functions, including changes in mitochondrial respiratory subunits, mitochondrial membrane potentials, ATP, and the NAD+/NADH ratio. NAD lactate dehydrogenase B Mus musculus
3 On the contrary, the induction of LDHB expression caused enhanced mitochondrial functions, including changes in mitochondrial respiratory subunits, mitochondrial membrane potentials, ATP, and the NAD+/NADH ratio. NAD lactate dehydrogenase B Mus musculus