Title : IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis.

Pub. Date : 2020

PMID : 32410852






2 Functional Relationships(s)
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1 We have previously shown that the T helper- (Th-) type 2 cytokines, Interleukin- (IL-) 4 and IL-13, mediate CD4+ T cell- or B cell-driven inflammation in the oxazolone-induced mouse model of ulcerative colitis. Oxazolone interleukin 4 Mus musculus
2 These results suggest that IL-4/IL-13 signalling through IL-4Ralpha on nonhematopoietic intestinal epithelial or smooth muscle cells and hematopoietic macrophage/neutrophils has a redundant role in driving acute oxazolone colitis. Oxazolone interleukin 4 Mus musculus