Pub. Date : 2020 May 15
PMID : 32410728
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | The widely prescribed cholesterol uptake inhibitor, ezetimibe, blocks NPC1L1; we show that residues that lie at the interface between NPC1L1"s three extracellular domains comprise the drug"s binding site. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 5 | The widely prescribed cholesterol uptake inhibitor, ezetimibe, blocks NPC1L1; we show that residues that lie at the interface between NPC1L1"s three extracellular domains comprise the drug"s binding site. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 6 | These data support a model in which cholesterol passes through the cores of NPC1/NPC1L1 proteins; concerted movement of various domains is needed for transfer and ezetimibe blocks transport by binding to multiple domains simultaneously. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |