Title : Dysregulated Brain Cholesterol Metabolism Is Linked to Neuroinflammation in Huntington's Disease.

Pub. Date : 2020 Jul

PMID : 32410324






1 Functional Relationships(s)
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1 The interaction of mutant huntingtin with sterol regulatory element-binding proteins is of particular interest given that sterol regulatory element-binding proteins play a dual role: They take part in lipid and cholesterol metabolism, but also in the inflammatory response that induces immune cell migration as well as toxic effects, particularly in astrocytes. Sterols huntingtin Homo sapiens