Pub. Date : 2020 May 13
PMID : 32404918
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carbidopa suppresses prostate cancer via aryl hydrocarbon receptor-mediated ubiquitination and degradation of androgen receptor. | Carbidopa | androgen receptor | Homo sapiens |
| 2 | In the present study, we report that Carbidopa suppresses the growth of PCa by downregulating the protein expression of AR. | Carbidopa | androgen receptor | Homo sapiens |
| 3 | Carbidopa increases ubiquitination of AR in LNCaP cells. | Carbidopa | androgen receptor | Homo sapiens |
| 4 | Quantitative RT-PCR, immunofluorescence staining and immunoblotting assay demonstrate that AHR is induced and activated by Carbidopa, and the co-immunoprecipitation assay shows that AR interacts with AHR, firmly confirming that Carbidopa decreases AR protein level though AHR-induced proteasomal degradation. | Carbidopa | androgen receptor | Homo sapiens |
| 5 | Quantitative RT-PCR, immunofluorescence staining and immunoblotting assay demonstrate that AHR is induced and activated by Carbidopa, and the co-immunoprecipitation assay shows that AR interacts with AHR, firmly confirming that Carbidopa decreases AR protein level though AHR-induced proteasomal degradation. | Carbidopa | androgen receptor | Homo sapiens |