Title : The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa.

Pub. Date : 2020 Jul 17

PMID : 32404369






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Among these enzymes, thiamine monophosphate kinase (ThiL) catalyzes the final step of this pathway, phosphorylating thiamine monophosphate to produce TPP. Thiamine Pyrophosphate acetyl-CoA acetyltransferase 1 Homo sapiens
2 We demonstrate that thiL deletion abolishes not only thiamine biosynthesis but also thiamine salvage capability and results in growth defects of the DeltathiL strain even in the presence of thiamine derivatives, except for TPP. Thiamine Pyrophosphate acetyl-CoA acetyltransferase 1 Homo sapiens