Title : Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins.

Pub. Date : 2020 Jul 7

PMID : 32402249






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The causative agent of Huntington"s disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich region (PRR), which promote and inhibit the aggregation propensity of the protein, respectively, by poorly understood mechanisms. Proline huntingtin Homo sapiens