Title : Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.

Pub. Date : 2020 Jul 1

PMID : 32401607






3 Functional Relationships(s)
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1 The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Superoxides cytochrome b-245, beta polypeptide Mus musculus
2 After 12 wk Western diet, ESMIRO/ApoE-/-/Nox2-/y mice had reduced EC superoxide generation and greater aortic relaxation to acetylcholine. Superoxides cytochrome b-245, beta polypeptide Mus musculus
3 These results demonstrate that insulin resistance is characterized by increased Nox2-derived vascular superoxide. Superoxides cytochrome b-245, beta polypeptide Mus musculus