Title : Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells.

Pub. Date : 2020 Jun

PMID : 32401166






2 Functional Relationships(s)
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1 Here, we report that 17beta-estradiol (E2), TAM, and FUL stabilize MORC2 (MORC family CW-type zinc finger 2), an emerging oncoprotein in human cancer, in a GPER1-dependent manner. Estradiol G protein-coupled estrogen receptor 1 Homo sapiens
2 Here, we report that 17beta-estradiol (E2), TAM, and FUL stabilize MORC2 (MORC family CW-type zinc finger 2), an emerging oncoprotein in human cancer, in a GPER1-dependent manner. Estradiol G protein-coupled estrogen receptor 1 Homo sapiens